Nature Reviews Immunology
Immunology is a diverse and growing discipline that can be defined as the study of the tissues, cells and molecules involved in host defence mechanisms, how the body defends itself against disease, and what happens when it all goes wrong. Nature Reviews Immunology provides in-depth coverage of this field, from fundamental mechanisms to translational aspects of basic research, and reviews the field’s most important developments. All Review and Perspective articles are carefully commissioned by the editors and written by leaders in the field. Articles are subject to rigorous peer review and provide high-quality and authoritative coverage of the field in each issue. Articles are carefully tailored by the editors to provide accessible information for non-specialists, and this is additionally enhanced with the use of Glossary terms and highlighted references. Each issue also contains Research Highlight articles – short pieces written by the editors that summarize the results from recent hot research papers.
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Nature Reviews Immunology
© 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
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Nature Reviews Immunology
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https://www.nature.com/articles/s41577-026-01314-1
Nature Reviews Immunology, Published online: 19 May 2026;
doi:10.1038/s41577-026-01314-1A preprint (now published in Cell) by Scharping et al. shows that proteostasis is required to preserve the progenitor potential of CD8+ T cells and prevent their terminal dysfunction when chronically stimulated.]]>
Yen-Tzu ChangFelix Clemens RichterWen Jiang
doi:10.1038/s41577-026-01314-1
Nature Reviews Immunology, Published online: 2026-05-19; | doi:10.1038/s41577-026-01314-1
2026-05-19
Nature Reviews Immunology
10.1038/s41577-026-01314-1
https://www.nature.com/articles/s41577-026-01314-1
https://www.nature.com/articles/s41577-026-01307-0
Nature Reviews Immunology, Published online: 18 May 2026;
doi:10.1038/s41577-026-01307-0García-Torralba et al. critically discuss key immunobiological features of human breast cancer, focusing on disease heterogeneity and its implications for the development of improved therapeutic options against this deadly disease.]]>
Esmeralda García-TorralbaSherene LoiRoberto SalgadoLorenzo GalluzziAitziber Buqué
doi:10.1038/s41577-026-01307-0
Nature Reviews Immunology, Published online: 2026-05-18; | doi:10.1038/s41577-026-01307-0
2026-05-18
Nature Reviews Immunology
10.1038/s41577-026-01307-0
https://www.nature.com/articles/s41577-026-01307-0
+ T cells in lupus nephritis]]>
https://www.nature.com/articles/s41577-026-01310-5
Nature Reviews Immunology, Published online: 12 May 2026;
doi:10.1038/s41577-026-01310-5CD8+ T cells infiltrating the kidneys contribute to lupus nephritis by retaining cytotoxic functions despite appearing to be terminally differentiated.]]>
+ T cells in lupus nephritis]]>
Yvonne Bordon
doi:10.1038/s41577-026-01310-5
Nature Reviews Immunology, Published online: 2026-05-12; | doi:10.1038/s41577-026-01310-5
2026-05-12
Nature Reviews Immunology
10.1038/s41577-026-01310-5
https://www.nature.com/articles/s41577-026-01310-5
https://www.nature.com/articles/s41577-026-01311-4
Nature Reviews Immunology, Published online: 11 May 2026;
doi:10.1038/s41577-026-01311-4Macrophages continuously ‘nibble’ healthy neighbouring cells, capturing minute amounts of cytosolic material that are preserved in specialized vesicles and preferentially routed for cross-presentation to CD8+ T cells.]]>
Lucy Bird
doi:10.1038/s41577-026-01311-4
Nature Reviews Immunology, Published online: 2026-05-11; | doi:10.1038/s41577-026-01311-4
2026-05-11
Nature Reviews Immunology
10.1038/s41577-026-01311-4
https://www.nature.com/articles/s41577-026-01311-4
https://www.nature.com/articles/s41577-026-01305-2
Nature Reviews Immunology, Published online: 08 May 2026;
doi:10.1038/s41577-026-01305-2T cells integrate signals from self-ligands not only during thymic development but also as they circulate through secondary lymphoid organs. These encounters with self in the periphery shape their activation and function, thereby ‘training’ T cells to interpret and respond to foreign antigens.]]>
Judith N. MandlHeather J. MelicharByron B. Au-YeungJohannes TextorLudger Klein
doi:10.1038/s41577-026-01305-2
Nature Reviews Immunology, Published online: 2026-05-08; | doi:10.1038/s41577-026-01305-2
2026-05-08
Nature Reviews Immunology
10.1038/s41577-026-01305-2
https://www.nature.com/articles/s41577-026-01305-2
https://www.nature.com/articles/s41577-026-01309-y
Nature Reviews Immunology, Published online: 06 May 2026;
doi:10.1038/s41577-026-01309-yHu et al. report that activated T cells can enhance antigen processing and presentation in tumour cells and dendritic cells through DNA transfer by extracellular vesicles.]]>
Kirsty Minton
doi:10.1038/s41577-026-01309-y
Nature Reviews Immunology, Published online: 2026-05-06; | doi:10.1038/s41577-026-01309-y
2026-05-06
Nature Reviews Immunology
10.1038/s41577-026-01309-y
https://www.nature.com/articles/s41577-026-01309-y
https://www.nature.com/articles/s41577-026-01304-3
Nature Reviews Immunology, Published online: 06 May 2026;
doi:10.1038/s41577-026-01304-3This Review compares the structure–function relationships of the apoptosome, inflammasomes and PIDDosome, which are the three main platforms activating the CARD-containing caspases caspase-9, caspase-1 and caspase-2, respectively. It highlights the consequences of genetic perturbations of these platforms and their therapeutic potential in humans.]]>
Mohamed LamkanfiLieselotte Vande WalleFelix EichinAndreas Villunger
doi:10.1038/s41577-026-01304-3
Nature Reviews Immunology, Published online: 2026-05-06; | doi:10.1038/s41577-026-01304-3
2026-05-06
Nature Reviews Immunology
10.1038/s41577-026-01304-3
https://www.nature.com/articles/s41577-026-01304-3
+ T cell dysfunction in cancer]]>
https://www.nature.com/articles/s41577-026-01308-z
Nature Reviews Immunology, Published online: 05 May 2026;
doi:10.1038/s41577-026-01308-zA preprint by Chen et al. identifies Dusp5 and Zfp219 as regulators of age-associated T cell dysfunction in the tumour microenvironment.]]>
+ T cell dysfunction in cancer]]>
Matthew BiancaTracy McGaha
doi:10.1038/s41577-026-01308-z
Nature Reviews Immunology, Published online: 2026-05-05; | doi:10.1038/s41577-026-01308-z
2026-05-05
Nature Reviews Immunology
10.1038/s41577-026-01308-z
https://www.nature.com/articles/s41577-026-01308-z